Basic Information
| Product Name | Dihydromyricetin / Myricetin |
|---|---|
| Synonym | Null |
| Latin Name | Ampelopsis megalophylla Diels et Gilg |
| CAS Number | 27200-12-0 / 529-44-2 |
| Part Used | Leaf |
| Origin | China |
| Trademark | JINGMU |
| HS Code | 2932999099 / 2942000000 |
| Grade | Food Grade |
| Appearance | White Powder / Yellow Powder |
| Specification | 98% |
| Solubility | Slightly soluble in water |
| Test Method | HPLC |
| Free Sample | 20g or 50g is avaliable |
| Production Capacity | 2 Tons/Month |
Description
Dihydromyricetin (DMY) and Myricetin are bioactive flavonoids primarily extracted from the leaves of Ampelopsis grossedentata (commonly known as Vine Tea or Tengcha), a plant traditionally consumed in Southern China for centuries. These compounds are isolated using advanced techniques like supercritical CO₂ extraction or ethanol-water systems, yielding high-purity white to off-white crystalline powders with a slight bitter taste. DMY (C15H12O8) and Myricetin (C15H10O8) represent key health-promoting constituents of Vine Tea, offering diverse biological activities.
Function
1. Potent Antioxidant & Anti-Aging Effects
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Free Radical Scavenging: DMY and Myricetin directly neutralize reactive oxygen species (ROS), lipid peroxides, and hydroxyl radicals, protecting cells from oxidative stress.
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Anti-Lipid Peroxidation: Inhibit malondialdehyde (MDA) formation, reducing oxidative damage to lipids and proteins.
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Cellular Protection: Enhance endogenous antioxidants (SOD, GSH-Px) and activate Nrf2 pathways, slowing aging processes.
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Cosmetic Applications: Used in anti-aging skincare for brightening (tyrosinase inhibition), reducing wrinkles (collagen protection), and UV-radiation defense.
2. Neuroprotective & Cognitive Support
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Blood-Brain Barrier Penetration: DMY modulates neurotransmitter systems (e.g., GABA receptors), alleviating anxiety and improving sleep quality.
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Anti-Neuroinflammation: Suppresses TNF-α, IL-6, and NF-κB pathways, mitigating neuroinflammation linked to Alzheimer’s and Parkinson’s.
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Cognitive Enhancement: Improves learning/memory in models of cognitive impairment by reducing amyloid-β toxicity and tau hyperphosphorylation.
3. Cardiovascular and Metabolic Health
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Vasorelaxation: Promotes nitric oxide (NO) release, dilating blood vessels and improving microcirculation.
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Lipid Regulation: Lowers LDL cholesterol and triglycerides while elevating HDL, preventing atherosclerosis.
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Anti-Thrombotic: Inhibits platelet aggregation and PAF (platelet-activating factor), reducing thrombosis risk.
4. Hepatoprotective & Detoxification Effects
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Liver Protection: DMY shields hepatocytes from alcohol-induced damage by enhancing alcohol dehydrogenase (ADH) activity and accelerating ethanol metabolism.
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Anti-Fibrotic: Reduces hepatic steatosis and fibrosis via TGF-β1/Smad pathway modulation.
5. Anti-Diabetic and Anti-Obesity Activity
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Insulin Sensitivity: Activates AMPK/PI3K/Akt signaling, improving glucose uptake and reducing insulin resistance.
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Adipogenesis Inhibition: Suppresses PPARγ and C/EBPα expression, preventing fat accumulation.
6. Anti-Inflammatory and Immunomodulatory Actions
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Cytokine Suppression: Downregulates COX-2, iNOS, and pro-inflammatory cytokines (e.g., IL-1β).
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Immune Balance: Modulates T-cell differentiation and macrophage polarization.
Application
| Pharmaceuticals | Neuroprotective agents, liver detox formulations, anti-diabetic drugs. |
| Nutraceuticals | Antioxidant supplements, metabolic health boosters, hangover relief products. |
| Cosmetics | Anti-aging serums, whitening creams, UV-protective formulations. |
| Functional Foods | Healthy beverages, sugar-free products, weight-management foods. |
