Basic Information
| Product Name | Paeoniflorin |
|---|---|
| Synonym | Null |
| Latin Name | Malus Baccata |
| CAS Number | 23180-57-6 |
| Part Used | Root |
| Origin | China |
| Trademark | JINGMU |
| HS Code | 2932999099 |
| Grade | Food Grade |
| Appearance | Brown Powder |
| Specification | 50% |
| Solubility | Slightly soluble in water |
| Test Method | HPLC |
| Free Sample | 20g or 50g is avaliable |
| Production Capacity | 2 Tons/Month |
Description
Paeoniflorin (PF) is the principal bioactive monoterpene glycoside extracted from the roots of Paeonia lactiflora Pall. (White Peony), a plant revered in traditional Chinese medicine (TCM) for millennia. This compound represents the core active constituent of peony root extracts, contributing significantly to their therapeutic effects. PF is characterized by its distinct bitter taste and is typically isolated as a white crystalline powder.
PF is celebrated for its broad pharmacological properties, including anti-inflammatory, neuroprotective, immunomodulatory, hepatoprotective, and analgesic effects. Its multifaceted actions make it a cornerstone in TCM formulas targeting pain, inflammation, and neurological disorders. Modern research over recent decades has validated its potential benefits for conditions such as rheumatoid arthritis, neurodegenerative diseases, liver injury, depression, and cognitive dysfunction. Preliminary studies also suggest promise for alleviating colitis, neuropathic pain, and ischemia-reperfusion injuries.
Function
Paeoniflorin (PF) offers diverse therapeutic benefits, positioning it as a valuable natural compound. Here are its key properties and effects:
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Anti-Inflammatory & Immunomodulatory Effects:
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PF potently suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6) and mediators (e.g., COX-2, iNOS).
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It modulates immune cell activity (e.g., T-cells, macrophages) and inhibits NF-κB signaling, reducing systemic inflammation.
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Clinically significant for managing autoimmune disorders like rheumatoid arthritis.
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Neuroprotective & Cognitive Benefits:
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PF crosses the blood-brain barrier, protecting neurons from oxidative stress, excitotoxicity, and apoptosis.
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It enhances synaptic plasticity, promotes neurogenesis, and improves learning and memory.
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Shows therapeutic potential for Alzheimer’s disease, Parkinson’s disease, cerebral ischemia, and depression.
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Hepatoprotective Effect:
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PF shields liver cells from damage caused by toxins, alcohol, and viral hepatitis.
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It reduces liver inflammation and fibrosis by modulating hepatic stellate cell activation and oxidative stress pathways.
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Analgesic & Antispasmodic Effects:
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PF alleviates various types of pain (inflammatory, neuropathic, visceral) by modulating pain signaling pathways (e.g., opioid receptors, TRPV1).
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It relaxes smooth muscle, useful in treating conditions like irritable bowel syndrome (IBS) and menstrual cramps.
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Cardiovascular & Cerebrovascular Protection:
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PF improves microcirculation and protects vascular endothelial cells.
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It mitigates brain damage after stroke by reducing inflammation and oxidative stress.
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May help regulate blood pressure and prevent atherosclerosis.
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Anti-Depressant & Anxiolytic Effects:
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PF modulates neurotransmitter systems (e.g., serotonin, dopamine, GABA) and the HPA axis, exerting antidepressant and anxiety-reducing effects.
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Antioxidant Activity:
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PF directly scavenges free radicals and boosts endogenous antioxidant enzyme activity (e.g., SOD, GSH), combating oxidative damage.
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Application
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Pharmaceuticals: Core component in TCM formulas (e.g., Shaoyao Gancao Tang) and modern drugs
targeting arthritis, liver disease, neurodegenerative conditions, pain, and mental health disorders. -
Nutraceuticals & Functional Foods: Incorporated into supplements for joint health, cognitive support, stress relief, and liver detoxification.
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Cosmetics (Emerging Potential):
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Anti-Inflammatory & Soothing: Potential for calming irritated or sensitive skin (e.g., rosacea, eczema).
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Antioxidant & Anti-Aging: Protects skin cells from oxidative stress and environmental damage.
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Brightening: May inhibit melanogenesis, contributing to skin lightening effects.
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targeting arthritis, liver disease, neurodegenerative conditions, pain, and mental health disorders.
