Basic Information
| Product Name | Genistein |
|---|---|
| Synonym | Null |
| Latin Name | Sophora japonica Linn. |
| CAS Number | 65914-17-2 |
| Part Used | Fruit |
| Origin | China |
| Trademark | JINGMU |
| HS Code | 2938909090 |
| Grade | Food Grade |
| Appearance | Light yellow fine powder |
| Specification | 98% |
| Solubility | slightly soluble or insoluble in water |
| Test Method | HPLC |
| Free Sample | 20g or 50g is avaliable |
| Production Capacity | 2 Tons/Month |
Description
Genistein (98%) is a potent isoflavone primarily extracted and purified from the dried fruit pods (Fructus Sophorae) of the Sophora japonica L. tree (Huai Jiao, Pagoda Tree). This bioactive compound has been recognized in traditional medicine systems and modern science for its diverse physiological activities. The 98% purity extract is obtained using advanced purification techniques to concentrate this specific isoflavone, resulting in a fine, light yellow to off-white powder with characteristic solubility properties.
Genistein (98%) is renowned for its wide range of health-promoting properties. Preparations containing this high-purity isoflavone are utilized in pharmaceuticals, dietary supplements, functional foods, and cosmetic applications. Research over recent decades highlights its significant potential in areas related to hormonal balance, cellular health, cardiovascular function, and antioxidant protection.
Function
Genistein (98%) offers a broad spectrum of biological activities, making it a valuable nutraceutical and therapeutic agent. Here are its key properties and effects:
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Hormonal Balance & Menopausal Support:
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As a phytoestrogen, Genistein exhibits selective estrogen receptor modulator (SERM) activity. It can bind to estrogen receptors, particularly ERβ, potentially alleviating symptoms associated with menopause (like hot flashes and bone density loss) without the risks associated with stronger estrogens or synthetic hormone replacement.
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Antioxidant & Cellular Protection:
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Genistein is a potent antioxidant, effectively scavenging free radicals and reducing oxidative stress.
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It helps protect cellular components, including DNA, proteins, and lipids, from oxidative damage, contributing to overall cellular health and potentially slowing aging processes.
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Cardiovascular Support:
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Genistein contributes to cardiovascular health by improving endothelial function, promoting vasodilation, and potentially helping to regulate lipid profiles.
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Its antioxidant properties help protect low-density lipoprotein (LDL) from oxidation, a key step in atherosclerosis development.
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Cellular Signaling Modulation:
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A key mechanism of Genistein is its ability to inhibit specific tyrosine kinases, enzymes involved in signal transduction pathways that regulate cell growth, proliferation, and differentiation.
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This inhibition underpins its potential role in supporting healthy cell cycle regulation.
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Bone Health Support:
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By exerting estrogen-like effects on bone tissue and potentially inhibiting osteoclast activity (cells that break down bone), Genistein may help maintain bone mineral density and reduce the risk of osteoporosis, especially post-menopause.
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Potential Chemopreventive Properties:
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Extensive research investigates Genistein’s role in supporting cellular health and its potential chemopreventive effects against certain hormone-related cancers (e.g., breast, prostate) through multiple mechanisms, including hormonal modulation, tyrosine kinase inhibition, antioxidant effects, and induction of apoptosis (programmed cell death) in abnormal cells.
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Anti-inflammatory Effects:
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Genistein demonstrates anti-inflammatory activity by modulating the production and activity of inflammatory mediators (e.g., cytokines, prostaglandins, nitric oxide), potentially benefiting conditions associated with chronic inflammation.
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Effect on Specific Systems:
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Hormonal System: Modulates estrogenic activity via SERM effects, supporting hormonal balance.
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Skeletal System: Promotes osteoblast activity and inhibits osteoclast activity, contributing to bone density maintenance.
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Cardiovascular System: Enhances endothelial function and provides antioxidant protection to vascular tissues.
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Cellular Health: Influences key signaling pathways (tyrosine kinase inhibition) and protects against oxidative damage, supporting healthy cellular function and regulation.
Application
Applications in Cosmetics:
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Antioxidant Protection: Genistein’s potent free radical scavenging ability helps protect skin cells from oxidative stress caused by UV radiation and environmental pollutants, preventing premature aging.
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Anti-Aging: By combating oxidative damage and potentially supporting collagen synthesis/maintenance, Genistein helps reduce the appearance of fine lines and wrinkles and promotes a more youthful complexion.
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Skin Brightening: Research suggests Genistein may inhibit melanin synthesis, contributing to a more even skin tone and reduction in hyperpigmentation.
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Anti-Inflammatory: Its anti-inflammatory properties can help soothe irritated or sensitive skin.
