Phlorizin Phloretin

Product Name	Phlorizin / Phloretin
Synonym	Null
Latin Name	Malus Pumila
CAS Number	60-81-1 / 60-82-2
Part Used	Leaf
Origin	China
Trademark	JINGMU
HS Code	2938909090 / 2942000000
Grade	Food Grade
Appearance	White Powder
Specification	95%, 98%
Solubility	Slightly soluble or Very slightly soluble in water
Test Method	HPLC
Free Sample	20g or 50g is avaliable
Production Capacity	2 Tons/Month

Description

Phlorizin and Phloretin are key bioactive compounds naturally abundant in the roots, bark, and leaves of the apple tree (Malus domestica). Phlorizin serves as the primary precursor, which is metabolized in vivo into its active aglycone form, Phloretin. These compounds are extracted using solvents like ethanol or water, yielding a light tan to white crystalline powder with slight solubility in water. Renowned for their roles in glucose metabolism and antioxidant activity, they are increasingly utilized in pharmaceuticals, nutraceuticals, functional foods, and cosmetics.

Over the past two decades, research highlights Phlorizin and Phloretin’s potential in managing metabolic disorders like type 2 diabetes, obesity, and insulin resistance. Preliminary studies also suggest benefits for skin health, neurodegenerative conditions, and cardiovascular protection.

Function

Glucose Metabolism Regulation:
- Phlorizin is a potent, selective inhibitor of sodium-glucose cotransporters (SGLT1 and SGLT2) in the intestines and kidneys. This blocks glucose absorption and promotes renal glucose excretion, significantly lowering blood sugar levels.
- Phloretin enhances cellular glucose uptake by stimulating glucose transporter type 4 (GLUT4) translocation and inhibiting glucose uptake via GLUT2. This improves insulin sensitivity and helps maintain glycemic balance.
Anti-Diabetic & Anti-Obesity Effects:
- By reducing hyperglycemia and improving insulin signaling pathways, both compounds demonstrate strong potential in preventing and managing type 2 diabetes.
- Phloretin inhibits adipogenesis (fat cell formation) and promotes lipolysis (fat breakdown), aiding in weight management and combating obesity-related metabolic dysfunction.
Potent Antioxidant Activity:
- Phloretin is a highly effective antioxidant, directly scavenging reactive oxygen species (ROS) like superoxide anion radicals, hydroxyl radicals, and peroxynitrite.
- It enhances the activity of endogenous antioxidant enzymes (SOD, CAT, GPx) and boosts glutathione (GSH) levels, protecting cells from oxidative stress damage.
- This activity underpins benefits for aging, cardiovascular health, and neurodegeneration.
Anti-Inflammatory Effects:
- Both compounds suppress the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibit key inflammatory signaling pathways (NF-κB, MAPK).
- This reduces chronic low-grade inflammation associated with diabetes, obesity, and metabolic syndrome.
Cardiovascular Protection:
- By improving glucose/lipid metabolism and reducing oxidative stress/inflammation, they help protect vascular endothelium function.
- Studies indicate potential for lowering blood pressure and improving lipid profiles.
Neuroprotective Potential:
- Emerging research suggests Phloretin may protect neurons from oxidative damage and amyloid-beta toxicity, potentially slowing cognitive decline associated with aging and Alzheimer’s disease.

Application

Skin Brightening & Anti-Hyperpigmentation: Phloretin is a powerful inhibitor of tyrosinase, the key enzyme in melanin production. This makes it highly effective in reducing dark spots and promoting an even skin tone.
Anti-Aging & Antioxidant Protection: Its exceptional ability to neutralize free radicals protects skin cells from UV-induced damage and environmental stressors, preventing collagen degradation and reducing wrinkles.
Anti-Inflammatory & Soothing: Helps calm irritated skin and reduce redness associated with conditions like acne or rosacea.
Enhanced Penetration: Phloretin can improve the skin penetration of other beneficial active ingredients.