Ginkgo Biloba Extract

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Basic Information

Product NameGinkgo Biloba Extract
SynonymYajiaotong (Chinese); Maidenhair Extract; Ginkgo Extract; Extract Of Maidenhair Tree; Extract Of Ginkgo Biloba; Extract Of Ginkgo; Ginkgo Biloba Extract; Maidenhair Tree Extract; Ginkgo Biloba, Ext.; Maidenhair Tree Leaf Extract.
Latin NameGinkgo Biloba L.
CAS Number90045-36-6
Part UsedDried Leaf
OriginChina
TrademarkJINGMU
HS Code1302199099
GradeFood Grade
AppearanceBrown Powder
Specification24% Total flavones 6% Terpene lactones 5ppm Ginkgo
Solubility/
Test MethodHPLC
Free Sample20g or 50g is avaliable
Production Capacity2 Tons/Month

Description

Ginkgo Biloba Extract (GBE) is derived from the leaves of the Ginkgo biloba tree, which has been utilized medicinally in China for centuries. This extract encompasses Ginkgo biloba total flavonoids, ginkgolides, and other active substances. GBE possesses a multitude of health benefits, including the ability to expand blood vessels, safeguard vascular endothelial tissue, regulate blood lipids, protect low-density lipoprotein, inhibit PAF (platelet activating factor), prevent thrombosis, and scavenge free radicals. It is processed using an appropriate solvent to enrich its active ingredients, resulting in a light yellow-brown, flowable powder with a bitter taste.

GBE is renowned for its effects on promoting blood circulation, removing blood stasis, and dredging collaterals. Preparations made from GBE are extensively used in various fields such as medicine, health care products, food additives, functional beverages, and cosmetics. Over the past 15 years, research has indicated that GBE may be beneficial in treating age-related mental and physical deterioration, dementia, peripheral vascular disease, and organic impotence. Furthermore, it may alleviate the severity of depression in individuals with cerebral dysfunction. Preliminary or uncontrolled studies also suggest potential benefits for patients suffering from tinnitus, vertigo, acute cochlear deafness, macular degeneration, cyclic edema, and asthma.

 

Function

Ginkgo Biloba Extract (GBE), derived from the ancient Ginkgo biloba tree, stands as a premier botanical supplement renowned for its extensive range of scientifically supported health benefits. Its unique phytochemical profile, particularly rich in flavonoids and terpene lactones, underpins its diverse physiological actions. Here’s a detailed overview of its key properties and effects:

Enhances Cerebral Function & Circulation: GBE acts as a potent cerebral vasodilator and rheological agent, significantly improving microcirculation and blood supply to the brain. This enhanced perfusion promotes cerebral metabolism, oxygen utilization, and glucose uptake by neurons. Consequently, GBE supports cognitive functions including memory consolidation, recall, learning capacity, information processing speed, and overall mental clarity. Its efficacy is particularly noted in addressing age-related cognitive decline, hypofunction, and peripheral circulatory disorders. GBE is a valuable adjunctive therapy in managing conditions like vascular dementia and Alzheimer’s disease, where it may help stabilize or modestly improve cognitive symptoms.

Supports Cardiovascular Health: GBE exerts protective effects on the cardiovascular system. It contributes to the amelioration of blood lipid profiles by influencing cholesterol metabolism and reducing blood viscosity. Furthermore, GBE possesses vasoregulatory properties, helping to maintain healthy blood pressure levels and improve endothelial function. These combined actions—improving blood fluidity, reducing platelet aggregation (under specific conditions), and enhancing vessel tone—make GBE a significant contributor to the prevention and management of cardiovascular diseases.

Powerful Antioxidant & Anti-Aging Effects: As a formidable antioxidant, GBE effectively scavenges harmful free radicals and inhibits oxidative stress, a primary driver of cellular aging and damage. This protective mechanism extends to various tissues, including the skin. By mitigating oxidative damage to skin cells and supporting microcirculation, GBE contributes to a more youthful appearance, potentially reducing the visibility of wrinkles, improving skin tone and elasticity, and offering protective effects against environmental stressors, aligning with its reputation for promoting longevity.

Improves Peripheral Circulation & Alleviates Discomfort: Beyond the brain, GBE’s vasodilatory effects enhance blood flow throughout the peripheral vascular system. This improved circulation is particularly beneficial for alleviating symptoms like cold extremities, numbness, tingling (“pins and needles”), and pain (paraesthesia) in the hands and feet, often associated with compromised peripheral blood flow.

Traditional Tonic Actions (Kidney & Brain Nourishment): Rooted in traditional systems like Chinese medicine, GBE is revered for its ability to “tonify the Kidneys and nourish the Brain.” Modern interpretations link this to its effects on improving cerebral and systemic circulation, enhancing energy metabolism, and providing neuroprotective antioxidants, thereby supporting overall vitality, resilience, and cognitive sharpness – aspects traditionally associated with robust Kidney and Brain function.

Boosts Immune Resilience: GBE contributes to a fortified immune system through multiple pathways. Its antioxidant properties protect immune cells from oxidative damage, while improved circulation ensures efficient delivery of immune cells and signaling molecules throughout the body. By mitigating systemic inflammation and supporting cellular health, GBE enhances the body’s innate defense mechanisms.

Application

Ginkgo biloba extract (GBE), derived from one of the world’s oldest tree species, is renowned for its extensive and diverse health benefits, exerting positive effects across multiple physiological systems. Its complex phytochemical profile, rich in flavonoids, terpenoids (notably ginkgolides and bilobalide), and organic acids, underpins its wide-ranging therapeutic actions. Below is a detailed exploration of its primary biological effects and applications:

1. Neuroprotective & Cognitive Enhancement Effects:

  • PAF Inhibition & Neuro-Immune-Endocrine Modulation: GBE actively modulates the critical relationship between the immune system and the central nervous system. A key mechanism is its potent inhibition of Platelet-Activating Factor (PAF), a potent inflammatory mediator. This inhibition contributes to neuroprotection and influences endocrine interactions relevant to brain health.

  • Enhanced Cerebral Perfusion and Metabolism: GBE significantly improves cerebral blood flow (vasodilation) and optimizes brain energy metabolism. This dual action enhances oxygen and nutrient delivery to neural tissues, directly supporting cognitive functions, including learning and memory consolidation, as documented in studies like those cited on Chemicalbook.

  • Anti-Hypoxic & Memory Protection: GBE demonstrates a robust ability to counteract hypoxia (oxygen deficiency) in the brain. Its efficacy in ameliorating memory impairment induced by agents like sodium nitrite (NaNO₂) is attributed to increased cerebral circulation and improved utilization of energy substrates under hypoxic stress.

  • Clinical Application in Stroke: Specific constituents within GBE, particularly Ginkgolide B, have shown significant clinical promise in the treatment and management of stroke, primarily due to their potent anti-PAF activity and neuroprotective properties.

2. Cardiovascular Protective Effects:

  • GBE contributes substantially to the prevention and management of cardiovascular diseases through several synergistic mechanisms. These include improving peripheral and microvascular circulation, reducing blood viscosity, inhibiting platelet aggregation (anti-thrombotic effects), enhancing endothelial function, and providing antioxidant protection to vascular tissues.

3. Anti-Aging Effects:

  • The flavonoid complex within GBE, including key compounds like isoginkgetin, bilobalide, ginkgolides, and quercetin, exhibits powerful inhibitory activity against lipid peroxidation – a primary driver of cellular aging. Quercetin, in particular, is recognized for its exceptional potency in scavenging the free radicals that initiate and propagate this damaging process, thereby protecting cellular membranes and structures.

4. Potent Antioxidant Effects:

  • GBE possesses remarkable broad-spectrum antioxidant capabilities. It directly neutralizes various harmful reactive oxygen species (ROS), including lipid free radicals (LO•), lipid peroxyl radicals (LOO•), and alkyl radicals (R•). By effectively terminating free radical chain reactions, GBE shields cells, proteins, and DNA from oxidative stress and damage, a fundamental mechanism underlying its anti-aging and disease-preventive properties.

5. Applications in Cosmetics & Skincare:
Leveraging its potent bioactive profile, GBE has become a highly valued ingredient in cosmetic formulations, offering targeted benefits for skin health and appearance:

  • Anti-Aging: The concentrated flavonoids (ginkgo flavone glycosides, quercetin) and terpenoids in GBE combat skin aging by powerfully inhibiting lipid peroxidation within skin cell membranes. This protects against loss of elasticity, wrinkle formation, and degradation of the extracellular matrix (e.g., collagen and elastin). Quercetin stands out for its particularly strong activity in this domain.

  • Antioxidant Protection: GBE’s ability to directly scavenge a wide array of skin-damaging free radicals (lipid radicals, peroxyl radicals, alkyl radicals) makes it a superior cosmetic antioxidant. It interrupts oxidative cascades induced by UV radiation and environmental pollutants, preventing premature aging and photodamage.

  • Anti-Inflammatory & Soothing: Components like ginkgolides contribute anti-inflammatory effects, helping to calm irritated skin, reduce redness, and improve conditions like sensitive or reactive skin.

  • Enhanced Microcirculation: Topical application can promote superficial blood flow in the skin, contributing to a healthier, more radiant complexion and potentially aiding nutrient delivery to skin cells.

 

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